NanoClusters Enhance Drug Delivery in Mechanical Ventilation
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چکیده
منابع مشابه
Formulations and Inhaler for Patients on Mechanical Ventilation
Patents: To deliver drugs to patients on mechanical ventilation, the drug particles have to successfully navigate through an endotracheal tube and the ventilator tubing. Liquid formulations (e.g. nebulized) normally used with these patients are inefficient. Large amounts of drugs are deposited in the endotracheal tube and within the ventilator circuit. Dry powders offer an alternative formulati...
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Pressurized metered-dose inhalers (pMDIs) and nebulizers are routinely employed for aerosol delivery in mechanically ventilated patients. A significant proportion of the aerosol deposits in the ventilator circuit and artificial airway, thereby reducing the inhaled drug mass. Factors influencing aerosol delivery during mechanical ventilation differ from those in spontaneously breathing patients....
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BACKGROUND Bronchodilators are increasingly being used in patients undergoing mechanical ventilation. There are multiple factors that affect bronchodilator delivery during mechanical ventilation. These factors can be classified into three categories: ventilator-related factors, circuit-related factors and device-related factors. AIMS The purpose of this paper is to review in depth each of the...
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In selected patients, noninvasive positive pressure ventilation (NIPPV) with a facemask is now commonly employed as the first choice for providing mechanical ventilation in the intensive care unit (ICU). Aerosol therapy for treatment of acute or acute-on-chronic respiratory failure in this setting may be delivered by pressurized metered-dose inhaler (pMDI) with a chamber spacer and facemask or ...
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INTRODUCTION Patients receiving invasive mechanical ventilation with an endotracheal tube (ETT) can often benefit from pharmaceutical aerosols; however, drug delivery through the ventilator circuit is known to be very inefficient. The objective of this study was to improve the delivery of aerosol through an invasive mechanical ventilation system by redesigning circuit components using a streaml...
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